B P International

Aim: The aim of this study was to retrospectively review the patient profiles with liver diseases in order to determine the frequency of medication errors among patients with liver diseases. Study Designed: Retrospective study was performed. Place and Duration of Study: Abbasi Shaheed Hospital (ASH), Civil Hospital (CIVIL) and Dow University Hospital (DUH) Karachi Pakistan, conducted from April 2014 to June 2014. Methodology: The retrospective study was conducted by evaluating 61 patient profiles. These patients were admitted in three different hospitals of Karachi city mentioned above. Toxic hepatitis or drug-induced liver injury comprises a spectrum of clinical diseases that initiates with mild biochemical abnormalities and extends to acute liver failure. In this study 61patient’s profiles were collected and evaluated. The patients were aged 25 years and above. A quantitative analysis and investigation of clinically significant drug-drug interactions, drug-dis...

Possibility of occurrence of drug interactions increases with the number of drugs administered. Drug interactions can be classified in a number of ways using different basis as well as terminology. Drugs may interact with other drugs, foods, beverages, contrast media, and herbs; outside or inside the body. The term “drug-condition interaction” is sometimes used when the existing medical condition makes certain drugs potentially harmful. Knowledge of In vitro interactions is essential to avoid loss of activity of drugs before administration. Although every theoretical drug interaction may not manifest in practice, “drug interactions” is a prominent cause of adverse or undesired events related to drug administration or treatment failure. Amongst the herbs, St. John’s wort has a potential of producing significant drug interactions due to its capacity to induce metabolism of number of drugs. In vivo interactions at pharmacokinetic level affect absorption, distribution, biotransformation...