Measuring the Alkylation Kinetics and Drug Likeness of Four Novel Antineoplastic Compounds | Chapter 05 | Advances in Applied Science and Technology Vol. 4
Aims: To synthesize small molecule alkylating compounds and analyze the kinetics of the alkylation in aqueous solution. Determine molecular properties and the drug likeness of these four compounds as potential antineoplastic agents and apply statistical analysis to identify interrelationships of properties. Study Design: Four compounds were synthesized, characterized, and studied for alkylation capability. The alkylation kinetics was elucidated, as well as drug likeness properties. The interrelationships of properties were examined by statistical methodology. Place and Duration of Study: Department of Chemistry, Durham Science Center, University of Nebraska at Omaha, Omaha NE, from May 2015 to June 2015. Methodology: Four compounds were modified by the covalent bondin...