The Effect of Ethanol Extract of Xylopia aethiopica Fruits on the Histomorphology of the Kidney of Albino Wistar Rats: Advanced Study | Chapter 7 | Trends in Pharmaceutical Research and Development Vol. 1
Aims: The study investigated the effect of ethanol extract of Xylopia aethiopica fruits on the histomorphology of the kidney of albino Wistar rats. Study Design: Twenty (20) albino Wistar rats weighing between 130–180 g were assigned into four (4) groups of five rats each. Group 1 served as the control group. Groups 2, 3 and 4 received orally, 250 mg, 500 mg and 750 mg of Xylopia aethiopica ethanol extract per kilogram body weight respectively for twenty-eight (28) days. Place and Duration of Study: Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Akwa Ibom State, Nigeria. Methodology: The body and kidney weights were observed and kidney was excised for histological studies using haematoxylin and eosin staining techniques. Results: The final body and kidney weight showed significant weight increases in test groups compared with the control. The photomicrographs revealed gradual epithelial lining degeneration, vascular degeneration, inflammation and ren...