B P International

The compound, 4-[(3,5-dimethyl-1 H -pyrazol-1-yl)methyl]-4-methyl-2-phenyl-4,5-dihydrooxazole 2 was prepared in high yield, through nucleophilic substitution reaction of the O-tosyloxazoline derivative 1 , by heating in dimethyl sulfoxide (DMSO) and in presence of KOH as base. The structure of the synthesized compound was established on the basis of NMR spectroscopy ( 1 H, 13 C), MS data and elemental analysis. Author(s) Details Sara Hajib Doctoral Training “Bioactive Molecules, Health and Biotechnology”, Faculty of Sciences Dhar El Mahraz, Center of Doctoral Studies “Sciences and Technology”, LCO, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco. Younas Aouine Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco and ...

The amino ester derivative was synthesized via N -alkylation of methyl a -azido glycinate N -benzoylated 1 with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1 H-NMR, 13 C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria ( Bacillus subtilis and Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa and Salmonella enteric ) . The synthesized compound showed an interesting inhibitory effect against all the strains tested. Author(s) Details Hassane Faraj Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco. Abdelilah El Hallaoui Organic Chemistry Laboratory (LCO), Faculty of Sciences Dha...