B P International

Background: Acute discomfort during the perioperative period is deleterious to the postoperative result, and appropriate analgesia improves the outcome. It raises the body's sympathetic response, resulting in increased oxygen consumption, increased risk of deep vein thrombosis due to immobility, and pulmonary embolism. Methods: Sixty ASA I/II patients between the ages of 18 and 65 who underwent laparoscopic cholecystectomy and appendicectomy were randomly assigned to one of two groups. Patients with an ASA III/IV rating, those who had already received opioid or alpha 2 agonist treatment, and those who needed substantial surgical dissection were excluded. Prior to extubation, Group D got 1 g/kg IV Dexmedetomidine over 10 minutes, followed by 0.2-0.7 g/kg/hr, while Group P received 15 mg/kg IV Paracetamol. After extubation, patients' hemodynamics were followed and their VAS scores were measured for the next 24 hours. The time interval between the requirement of the first dosage...

The present study was undertaken to investigate the antioxidant and hepatoprotective effect of Spilanthes paniculata Wall. ex DC flower extracts against paracetamol-induced liver damage. The study was conducted in 36 male Wistar rats of either sex, and six groups were established. While the first group was maintained as normal control (NC, distilled water), Groups 2 to 6 were administered 3 g/kg Paracetamol (PAR) for 2 day, 100 mg/kg Silymarin (SMR), 500 mg/kg Methanolic extract (MESP), Petroleum ether extract (PEESP), Ethyl acetate extract of S. paniculata (EAESP) suspended in 0.5% tween 80 plus PAR, respectively. PAR was administered in the same schedule as in group 2, the treatment with silymarin and extracts was given for 10 days orally, respectively. It was observed that PAR significantly increased serum Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP) activity liver MDA levels (P<0.01) and significantly decreased liver Glutathione (GSH), ca...