B P International

Infection with the coronavirus that causes severe acute respiratory syndrome (SARS-CoV-2) and the sickness induced by the coronavirus. COVID-19 is a health and life-threatening virus that has gone unnoticed. In this study, we look at numerous possibilities that could explain why diabetic people infected with SARS-CoV-2 are more likely to develop a severe type of COVID-19 disease. Author(s) Details Dr. Radu Albulescu Nicolae Cajal’ Institute, ‘Titu Maiorescu’ University, 004051 Bucharest. National Institute for Chemical-Pharmaceutical R&D, 031299 Bucharest. Simona Olimpia Dima ‘Nicolae Cajal’ Institute, ‘Titu Maiorescu’ University, 004051 Bucharest, Romania and Fundeni Clinical Institute, 022328 Bucharest, Romania. Ioana Raluca Florea ‘Nicolae Cajal’ Institute, ‘Titu Maiorescu’ University, 004051 Bucharest, Romania and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania. Daniela Lixandru Fundeni...

Diabetic dyslipidaemia is the bane of most complications seen in diabetes mellitus. The aim of our study is to determine the levels of apolipoprotein B-100 among diabetic adults and non-diabetic control; and its relationship with the traditional lipid profile parameters. A total of 58 subjects including 30 diabetic patients and 28 non-diabetic controls selected from diabetic clinic and immunization centres respectively. Subjects were randomly selected, examined clinically and have their anthropometric parameters measured. Lipid profile was assayed using standard enzymatic spectrophotometric methods while serum apolipoprotein B-100 was measured using sandwich immunoassay technique. Data were expressed in means and standard deviations. Differences in means between the two groups were assessed using Student T-test and relationships tested using Pearson’s correlation study. Mean ages of diabetic and non-diabetic groups were 57.7±7.4 and 49.3± 17.9 years respectively (p>0.05). Stati...

This review aims to enlighten the readers regarding the past, present and future of stem cells in the treatment of Diabetes. Diabetes is one of the leading causes of morbidity and mortality, affecting more than 415 million people worldwide.  It is estimated that one in ten adults will have diabetes by 2030. Diabetes is mainly due to reduction in β-cell mass which are responsible for insulin production. Exogenous administration of insulin is having good impact on restoring glucose homeostasis, but it does not entirely control the minute-to-minute fluctuations in systemic blood glucose. Recently cellular-based therapies have been established for exogenous insulin administration by modern pump technology. One of the most interesting therapies involves substitution of insulin producing islet cells by transplantation. But lack of donor material and lifelong immunosuppression made the technique unfeasible. These restrictions have led to exploration of other sources of β-cells, one of ...

Aim: The aim of the present study was to assess the predicting powers of different adiposity indices on incident type 2 diabetes mellitus (T2DM) among adult men and women in Uyo Metropolis, Nigeria. Methodology: Three thousand five hundred adult civil servants (1532 men and 1968 women), aged 18 - 60 years, were assessed for incident T2DM using 2011 Expert Committee Revised criteria for the diagnosis of T2DM. Results: Incident T2DM was found in 180 (5.4%) participants, 73 men (4.8%) and 116 women (5.9%). Results of comparison between diabetic men and women showed that body mass index (BMI) and mid arm circumference (MAC) did not differ significantly between groups. Waist circumference (WC) and waist-hip ratios (WHR) of women with T2DM were significantly higher than those of men with T2DM (WC: P =0.001 and WHR: P=0.034). BMI and MAC had equal predicting powers in both genders with odds ratios (OR) and 95% confidence intervals (CI) as follows: BMI (OR=2.41, C.I=1.728 -...

The combined anti-diabetic effects of Extracts of Artemisia annua var. chiknensis with Laboratory code number (CBGE/CHINA/09/LTNGS/G), Momordica charantia Linn, Vernonia amygdalina Del. and Aegle marmelos Correa traditionally employed in Nigeria for the treatment of diabetes were studied. Fifty male albino rats which had been subjected to overnight fasting were rendered diabetic through single intraperitoneal alloxan injections (120 mg/kg body weight). They were then divided into 5 batches of ten rats each. The first batch was treated with A. annua leaf extract only. The second batch was treated with a combination of A. annua and M. charantia extracts. The third batch was treated with a combination of A. annua and V. amygdalina extracts while the fourth batch was treated with a combination of A. annua and Aegle marmelos extracts. The extracts were used in the ratio of 1:1 and treatment was done twice daily for a period of 30 days. The fifth batch of diabetic rats was not treated and...

Gongronema latifolium is a plant that has a wide range of nutritional and ethnomedical uses in different tropical African communities. Scientific reports on the chemical composition and bioactivity (anti-inflammatory, antimicrobial, antidiabetic, antioxidant, anticancer and allelopathic properties) of the plant material by different authors are discussed in this review. Future prospects of the plant extracts in the areas of herbal formulations, food preservation, alcoholic fermentation and beer production, drug discovery and allelopathy are also highlighted. Author   Details: Olugbenga Morebise Faculty of Basic Medical Sciences, All Saints University School of Medicine, Roseau, Commonwealth of Dominica. Read full article: http://bp.bookpi.org/index.php/bpi/catalog/view/50/403/433-1 View Volume: https://doi.org/10.9734/bpi/rabr/v3