Phytomedicinal and Ameliorative Effect of Ethanol Leaf Extract of Corchorus olitorius on Carbon Tetrachloride Induced Hepatic Toxicity | Chapter 01 | Recent Advances in Biological Research Vol. 5
Liver, the engine house for biotransformation of xenobiotics serves as a receiving depot, processing factory and redistribution center of the body. In the light of these roles, the effect of ethanol leaf extract of Corchorus olitorius on CCl 4 induced liver damage in wistar rats was assessed. CCl 4 (0.5 ml/kg) was used to induced hepatotoxicity. 25-albino rats of wistar strain (120-150 g) were used for the study and were divided into five groups of five rats per group. Group A serves as normal control and was given distilled water of treatment equivalence, group B serves as a negative control and was treated with CCl 4 and olive oil as a vehicle at the ratio of 1:1. Group C, D, and E were induced with CCl 4 and the extract administered through oral gavages at scalar doses of 500 mg/kg, 750 mg/kg and 1 g/kg daily. The administration lasted for 15 days period after which the animals were sacrificed. Serum enzyme assay revealed that there was a marked reduction in the elevated acti...