Studies on Alzheimer Disease - Metformin Connection - A Brief Review | Chapter 02 | Emerging Trends and Research in Biological Science Vol. 1
Metformin is the widely prescribed first line oral antidiabetic drug used in diabetes mellatus, type 2. The global sales turnover of metformin runs into millions of dollars. The Increased risk of metformin (Met) users for developing Alzheimer disease (AD) is reported first in a study conducted in 2011. Since then, the subject has attracted the attention of the researchers as well as the pharmaceutical industry, resulting in a number of studies, both clinical as well as experiments on animals. Confusing results poured in, ranging from confirmation of the risk of AD to protection against developing AD, making the scenario, all the more intriguing. Added to the confusion, is the diversity of various studies as well as the parameters interpreting their results. Of the many clinical trials, some are retrospective cohort studies (Tseng Chin-Hsiao [1]), case control studies (Imfeld P, et al. [2]) Randomised studies (Hsu CC, et al. [3]), double blind, cross over pilot studie...