Structure, Properties, and Drug-likeness of Pharmaceuticals That Inhibit Ebola Virus Disease (EVD) Proliferation | Chapter 01 | Current Trends in Disease and Health Vol. 1
Introduction: The Ebola virus is one of known viruses within the genus Ebolavirus that are generally considered to cause Ebola virus disease (EBV) in humans. Some investigators have determined that Ebola virus outbreaks have an increased likelihood to occur when temperatures are lower and humidity is higher. The determination and evaluation of pharmacokinetic and pharmacodynamics properties of drugs potentially useful for treatment of Ebola virus disease is a very important consideration for discovery of new pharmaceuticals. Aims: To present the molecular structures of compounds that has been shown to inhibit the proliferation of Ebola virus. To elucidate the molecular properties of these virus inhibiting compounds. Study Design: The molecular properties of virus inhibiting compounds are elucidated and compiled. Pattern recognition methods and statistical analysis are applied to determine optimal properties of this group of compounds. Place and Duration of Study: Chemi...