First Detection of Ketoreductase in the Genome of Potentially Pathogenic Fast-Growing Environmental Mycobacteria Isolated in Ivory Coast | Chapter 04 | Recent Advances in Biological Research Vol. 3
Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer (BU), skin disease, is considered to be an environmental pathogen. The pathogenic virulence of MU is being linked to the expression of toxin called Mycolactone. The ketoreductase (KR) gene, is one of the synthesis genes of mycolactone enzymes previously found in M. ulcerans. Genetic analyses using variable number tandem repeats (VNTR) and mycobacterial interspersed repetitive units (MIRU) have shown high diversity in M. ulcerans and in mycolactone producing Mycobacteria (MPMs). Aim: The purpose of this study is to detect ketoreductase gene in the genome of environmental mycobacteria strain, apart the M. ulcerans, from aquatic environments in Côte d’Ivoire. Place and Duration of the Study: The analysis of the samples took place in the laboratories of Institut Pasteur de Côte d’Ivoire in Abidjan City between June 2014 and December 2015. Sampling was done in some hypoendemic and hyperendemic sites of Bur...