Homeopathic Drug improve Metabolic Abnormalities Induced by HAART in Mice | Chapter 12 | Modern Advances in Pharmaceutical Research Vol. 1
Aims: Highly Active Antiretroviral Therapy (HAART) has changed the natural history of HIV infection, several adverse events may limit its efficacy. Antiretroviral drugs are associated with increased risk of severe hepatotoxicity. Homeopathy is a popular form of complementary and alternative medicine and is used to treat certain liver ailments. Chelidonium majus has a long history in the treatment of several diseases exhibit apoptotic activity, antioxidant and hepatic-protective effects. Current study evaluated the effect of homeopathic formulations of C. majus on metabolic alterations induced in mice subjected to HAART. Methodology: Four-week old male Swiss Webster mice, weighing approximately 28-30 g, provided by the Central Animal Laboratory of the State University of Maringá, were used in the experiments. Five experimental groups with 10 animals each were distributed as follows: (I) animals treated with HAART diluted in 1.2 mL water gavage/day, (II) animals treated with HAA...