B P International

Background: The carriage of Staphylococcus aureus in the anterior nares of subjects in the study environment has not been carried out before and this study is thus a reference study against which future studies can be compared. The isolates obtained were also tested against frequently used antibiotics as well as linezolid, an antibiotic which is of considerable importance in the treatment of Methicillin Resistant Staphylococcus aureus (MRSA). Methods: A total of 400 nasal swabs were collected from anterior nares of apparently healthy subjects aseptically using a sterile swab sticks. The antibiotic susceptibilities of isolates of S. aureus obtained against eight different antibiotics including Linezolid were determined using the disc-plate method. Results: The results showed that 91 (22.8%) of the subjects tested are nasal carriers of S. aureus. The incidences of resistance observed with each of the antibiotics tested were as follow: Erythromycin 83(91.2%), Tetracy...

This research work aimed to present the activity guided fractionation with antimicrobial evaluation from both crude extract and various fractions obtained from Pergularia tomentosa L. whole plant. The P. tomentosa L. whole plant was extracted with 95% aqueous ethanol; fractionated into acidic, basic, polar and nonpolar fractions. All fractions with the crude extract were screened for both antimicrobial and minimum inhibitory concentration (MIC) potentialities. For crude extract, all concentrations (1.5, 0.75, 0.35, & 0.168 mg/ml) indicated marginal antibacterial activity with range of 17, 20, 14 mm zone of inhibition for S. aureus, E. coli and C. albicans. While, both basic fraction showed highest activity against E. coli and C. albicans at 15 mm & 15 mm; along with acidic and methanolic fraction haven large spectrum against S. aureus, E. coli and C. albicans at 13, 12, 12 mm. Moreover hexane did not showed antimicrobial activity for both S. aureus and C. albicans except for ...