A Comparative Study on In-vivo Biocompatibility of Four Endodontic Sealers | Chapter 6 | New Frontiers in Medicine and Medical Research Vol. 11
The goal of this study was to compare the biocompatibility of two new calcium phosphate-based root canal sealers (CPC-I, CPC-II) to a commercially available zinc oxide eugenol-based sealer [Pulp canal sealer EWT (PCS EWT)] and Sealapex after implantation in rat subcutaneous tissue. The test ingredients were placed in sterile polyethylene tubes. The tubes were implanted in the dorsums of male rats, and the animals were euthanized after 1, 2, 4, and 8 weeks, yielding 5 specimens for each treatment. As a negative control, empty tubes were used. Inflammation, major cell types, and fibrous connective tissue thickness were all quantified next to each inserted sample. All sealers generated similar inflammatory reactions in the animals' connective tissue at week one, with the majority of specimens demonstrating a moderate to severe chronic inflammatory response. CPC-II and (PCS EWT) caused a severe inflammatory response with the presence of acute inflammatory cells after 2 weeks, whereas C...