B P International

The renin-angiotensin system (RAS) regulates blood pressure the most effectively, and angiotensin II is the main mediator in this system. Angiotensin II binds to AT1 receptors and causes a multitude of potentially detrimental effects, including blood pressure elevation, atherosclerosis progression, and myocardial and vascular hypertrophy. Losartan was the first angiotensin receptor blocker (ARB) to be identified to reduce the risk of stroke and new-onset diabetes, as well as having a proven stroke benefit. The purpose of this study was to see how losartan affected various biochemical markers. Over a six-month period, researchers looked at the effects of monodrug (Losartan) therapy on blood sugar, lipid profile, uric acid, and serum electrolytes. The researchers looked at twenty-nine newly diagnosed essential hypertension patients of both genders. Before starting losartan monotherapy, baseline values of lipid profile, serum electrolytes, fasting blood sugar, and uric acid were taken...

Blood transfusion is mandatory for treatment of a number of clinical conditions. Blood to be transfused needs to be stored for future use in blood banks. To prevent the risk of graft versus host disease, blood is irradiated with gamma radiation before storage. During storage, blood components undergo a variety of alterations known as storage lesions. These lesions might differ when blood is pre-irradiated as compared to non-irradiated one. Many reports are there to explain the alteration of a number of parameters in stored blood but literature is very scant regarding effect of blood storage on lipid profile. Through this chapter an attempt has been made to throw some light on effect of storage on lipid profile as well as to compare the effect in pre-irradiated and non-irradiated blood samples. Author(s) Details Dr. Kiran Dahiya Department of Biochemistry, Pt. BD Sharma PGIMS, Rohtak, Haryana, India. Rakesh Dhankhar Department of Radiotherapy, Pt. BD Sharma PGIMS, Ro...