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Study of Losartan’s Effects on Different Biochemical Parameters in Essential Hypertensive Patients | Chapter 12 | New Frontiers in Medicine and Medical Research Vol. 3

The renin-angiotensin system (RAS) regulates blood pressure the most effectively, and angiotensin II is the main mediator in this system. Angiotensin II binds to AT1 receptors and causes a multitude of potentially detrimental effects, including blood pressure elevation, atherosclerosis progression, and myocardial and vascular hypertrophy. Losartan was the first angiotensin receptor blocker (ARB) to be identified to reduce the risk of stroke and new-onset diabetes, as well as having a proven stroke benefit. The purpose of this study was to see how losartan affected various biochemical markers.


Over a six-month period, researchers looked at the effects of monodrug (Losartan) therapy on blood sugar, lipid profile, uric acid, and serum electrolytes.

The researchers looked at twenty-nine newly diagnosed essential hypertension patients of both genders. Before starting losartan monotherapy, baseline values of lipid profile, serum electrolytes, fasting blood sugar, and uric acid were taken, and they were repeated six months later. After six months of losartan medication, there was a significant rise in HDL cholesterol and a significant drop in blood uric acid levels when the means were compared. Blood sugar and electrolyte levels showed no significant differences.

Conclusion: These data indicate that losartan may be a viable therapy option for hypertension and metabolic syndrome.

Author (S) Details

Pratibha S. Salve
Department of Pharmacology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Chitra C. Khanwelkar
Department of Pharmacology, Krishna Institute of Medical Sciences, Karad, Maharashtra, India.

Preeti S. Salve
Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KAHER, Belagavi, India.

View Book :- https://stm.bookpi.org/NFMMR-V3/article/view/3147
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