Comparative Study between Anthracycline Based Regimen and Taxane Based Regimen in Metastatic Gastric Cancer: General Perspectives | Chapter 3 | Innovations in Medicine and Medical Research Vol.2
Introduction: Taxanes and anthracyclin containing regimes are the most successful regimens in advanced gastric cancer with comparable results but with different toxicity profiles. Objective: To compare efficacy and toxicity of 2 regimens one containing anthrathycline (ECSF regimen) and other contain taxane (PCF regimen) as a first line therapy in advanced gastric cancer. Methods: Between May 2011 and Dec 2015, a total of 120 patients with locally advanced and metastatic gastric adenocarcinoma were included in the study, 60 patients received ECSF (Epirubicin 50 mg/m2 iv d1, Cisplatin 60 mg/m2 iv d1, 5-FU 1750 mg/m2/d “1 and 8” CIVI over 24 h, Folinic acid 200 mg /m2 day 1, 8 repeated every 3 weeks), while, another 60 patients received PCF (Paclitaxel 150 mg/m2 IV on day 1; Cisplatin 15 mg/m2 IV on days 1-5 and 5-FU 600mg/m2/day CIVI d1-5 every 3 weeks) until disease progression or unacceptable toxicities. Results: ORR of ECSF was superior to PCF arm, 47% vs. 34% respe...