B P International

The epidermal growth factor receptor (EGFR) single nucleotide polymorphism (SNP) is important for disease progression and targeted therapy in head and neck cancer (HNC). As a result, the goal of this study is to find mutations in the EGFR gene (exon 20) in HNC who have been exposed to smoke and alcohol. On the study group of 129 HNC cases and 150 healthy volunteers, mutational analysis was performed using polymerase chain reaction (PCR) and single stranded confirmatory polymorphism (SSCP) techniques. There were four distinct SNPs identified (R776H, G779G, Q787Q, and L798H), with a mutation rate of 75.19 percent in HNC patients and 46 percent in controls. Q787Q was found to be more frequent (p,0.05), with genotypes GG, GA, and AA accounting for 24.80 percent, 61.24 percent, and 13.95 percent of the population, respectively. The researchers discovered that EGFR is a polymorphic gene linked to HNC illness, and that same SNPs were also identified in healthy people who smoked and drank. The...

The oncological treatment has been advanced promisingly over the past decades. The patients may be treated with surgery, chemotherapy (CT), radiotherapy (RT) or combination of these treatment modalities. Immunotherapy for prevention and treatment of malignant disease is also in initial stage and has raised a hope that improving immune mechanism can be of use. Most suitable treatment modality for the patient is selected after the final diagnosis. The use of Mycobacterium w (Mw) vaccine in Head and neck cancer (HNC) is an effort to reduce treatment induced toxicity with resultant improvement in the response rate. Immunotherapy in the form of Mw vaccine may be useful as concurrent therapy with radical intent concomitant chemo radiation treatment to improve response rate with less side effects in patients suffering from locally advanced head and neck squamous cell carcinoma Author (s) Details Dr. Rakesh Dhankhar   Department of Radiotherapy, Regional Cancer Centre, Pt. Bhagwat D...