Determination of Thiolated Chitosan as Nanocarriers for Ocular Drug Delivery | Chapter 12 | New Innovations in Chemistry and Biochemistry Vol. 2
Because of its complicated anatomical structure, drug administration via the ocular channel has become more interesting and demanding in recent years. Despite extensive efforts by medical scientists around the world, there are numerous hurdles to overcome in delivering drugs via the ocular route. Short ocular residence periods induced by anatomical and pathophysiological obstacles in the eye result in poor ocular bioavailability with traditional dose formulations. As a result, a lot of effort has gone into developing nanotechnology-based drug delivery systems that improve ocular bioavailability by increasing precorneal residence time. Polymers with thiol groups have substantially better adhesive characteristics than polymers that are assumed to be mucoadhesive in general. Chitosan and its derivatives are excellent polymeric biomaterials with a wide range of applications in drug delivery, especially via the ocular route. Thiolated derivatives (thiomers) of chitosan, which are made by im...