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Determination of Thiolated Chitosan as Nanocarriers for Ocular Drug Delivery | Chapter 12 | New Innovations in Chemistry and Biochemistry Vol. 2

Because of its complicated anatomical structure, drug administration via the ocular channel has become more interesting and demanding in recent years. Despite extensive efforts by medical scientists around the world, there are numerous hurdles to overcome in delivering drugs via the ocular route. Short ocular residence periods induced by anatomical and pathophysiological obstacles in the eye result in poor ocular bioavailability with traditional dose formulations. As a result, a lot of effort has gone into developing nanotechnology-based drug delivery systems that improve ocular bioavailability by increasing precorneal residence time. Polymers with thiol groups have substantially better adhesive characteristics than polymers that are assumed to be mucoadhesive in general. Chitosan and its derivatives are excellent polymeric biomaterials with a wide range of applications in drug delivery, especially via the ocular route. Thiolated derivatives (thiomers) of chitosan, which are made by immobilising thiol groups on the main amino groups of the chitosan backbone, have better mucoadhesive qualities by forming electrostatic contacts with mucin, as well as increased permeability and anti-protease activity. Furthermore, it is non-toxic, biocompatible, and biodegradable. Many medications and therapies can be delivered through the ocular route in nanoparticulate form or as in-situ gel forming systems using Thiolated chitosan. The major goal of this chapter is to give readers an overview of the many techniques to employing Thiolated Chitosan as a nanocarrier for ocular medication delivery by presenting recent results and applications in the field.

 

Author (S) Details

Divyesh H. Shastri
Department of Pharmaceutics, K. B. Institute of Pharmaceutical Education & Research, Kadi Sarva Vishwavidyalaya, Gandhinagar, Gujarat, India.


View Book :- https://stm.bookpi.org/NICB-V2/article/view/3589


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