B P International

 Background: Breast cancer heterogeneity is produced by a variety of factors such as patient characteristics, co-morbidities, histology, immunochemistry, and the disease's molecular type, leading in a wide range of treatment options. Despite advancements in breast cancer diagnosis and therapy, breast cancer remains the leading cause of death in Pakistani women. Several studies have found that chronic inflammatory disorders have a role in the progression of cancer; these factors also promote growth, which leads to a poor prognosis. The goal of this study is to look at the neutrophil to lymphocyte ratio (NLR) in breast cancer patients' blood and how it relates to disease characteristics. The cross-sectional study was conducted in Karachi, Pakistan, at Liaquat National Hospital and Medical College. A total of 2059 female breast cancer patients met the criteria. A thorough blood count with leukocyte differential was recommended for the patients prior to surgery. Complete patien...

Changes in glycosylation profiles have emerged as indicators of diseases. Altered glycans and glycoproteins secreted by pathological tissues are found in human serum and are potential glycobiomarkers for early diagnostic and prognostic of diseases such as inflammation, infection and cancer. To obtain serum samples is a simple procedure and minimally invasive; thus the detection of glycobiomarkers in serum is attractive for clinical applications. Electrochemical biosensors are a friendly strategy for rapid, easy and highly sensitive measuring of glycans and glycoprotein biomarkers. The use of lectins as biorecognition elements in glycobiosensors has provided a specific detection and profiling of glycans linked to glycoproteins. Electrochemical glycobiosensors based on lectin interactions employed to characterize glycan profiles in serum glycoproteins constitute a promising tool in diagnostic and monitoring of diseases. Author(s) Details Priscila Marcelino dos Santos Silva ...