Current knowledge of Epigenetic Events in Multiple Myeloma | Chapter 7 | New Frontiers in Medicine and Medical Research Vol. 5
Multiple myeloma (MM) is a physiologically heterogeneous illness characterised by a wide range of chromosomal, genetic, and epigenetic alterations. Without affecting the DNA sequence, epigenetic changes can influence gene function. DNA methylation and post-translational alteration of histone proteins (histone methylation, acetylation, and deacetylation) are two biochemical modifications that have a role in the pathogenesis of MM. Epigenetic DNA methyltransferases (DNMTs), ten-eleven translocation enzymes (TET), histone acetyltransferases (HATs), and histone deacetylases are examples of key specialised enzymatic entities that mediate changes (HDACs). Micro-RNA molecules have a role in epigenetic processes as part of a complicated machinery. Not only does epigenetics play a role in myeloma genesis, but it also has an impact on medication resistance and prognosis in individuals with MM. Author(s) Details Flodrova Pavla Department of Clinical and Molecular Pathology, Faculty of Me...