B P International

Introduction: The Ebola virus is one of known viruses within the genus Ebolavirus that are generally considered to cause Ebola virus disease (EBV) in humans. Some investigators have determined that Ebola virus outbreaks have an increased likelihood to occur when temperatures are lower and humidity is higher. The determination and evaluation of pharmacokinetic and pharmacodynamics properties of drugs potentially useful for treatment of Ebola virus disease is a very important consideration for discovery of new pharmaceuticals. Aims: To present the molecular structures of compounds that has been shown to inhibit the proliferation of Ebola virus. To elucidate the molecular properties of these virus inhibiting compounds. Study Design: The molecular properties of virus inhibiting compounds are elucidated and compiled. Pattern recognition methods and statistical analysis are applied to determine optimal properties of this group of compounds. Place and Duration of Study: Chemi...

Aims: To synthesize small molecule alkylating compounds and analyze the kinetics of the alkylation in aqueous solution. Determine molecular properties and the drug likeness of these four compounds as  potential  antineoplastic  agents  and  apply  statistical  analysis  to  identify  interrelationships  of properties. Study  Design: Four  compounds  were  synthesized,  characterized,  and  studied  for  alkylation capability.  The  alkylation  kinetics was elucidated,  as  well  as  drug  likeness  properties.  The interrelationships of properties were examined by statistical methodology. Place and Duration of Study: Department of Chemistry, Durham Science Center,  University  of Nebraska at Omaha, Omaha NE, from May 2015 to June 2015. Methodology: Four compounds were modified by the covalent bondin...