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Research on Evaluation of the Effect of Crude Extract of Datura innoxia on the Cardiovascular Action of Detomidine in Rabbits | Chapter 8 | Trends in Pharmaceutical Research and Development Vol. 1

Datura innoxia indigenous shrub in South Asia region belongs to the family Solanaceae which contains medicinal important alkaloids (hyoscine, atropine, hycosamine, etc). Thirty adult rabbits of mixed breed, male and female were pretreated with 0.1 mg/500 mg of crude extract (1% of dimethyl sulfoxide (DMSO) solution) and injected 5 min later with 0.01 mg/500 mg of detomidine (group A, n=15) or Saline (group B, n=15). Mean arterial pressure, measurements and electrocardiography were performed for 65 min. After injecting crude extract of D. innoxia, the heart rate was increased by 45 and 46.34% in groups A and B, respectively. Heart rate remained increased after the injection of detomidine returning to base line values after 15 min. No increase in the mean arterial  pressure (MAP) was noted in group B rabbits. Crude extract shortened PR and QT interval in both groups but after detomidine, PR and QT interval were enlarged significantly at the end of the experiment. The second degree ...

Influence of Dietary Supplementation of Coated Sodium Butyrate and/or Synbiotic on Growth Performances, Caecal Fermentation, Intestinal Morphometry and Metabolic Profile of Growing Rabbits | Chapter 09 | Research and Development in Agricultural Sciences Vol. 2

Aim: The aim of the present experiment was to study the synergistic effects of dietary supplementation with coated slow released sodium butyrate (CM3000 ® ) and a commercial synbiotic (Poultry-Star ® ) on the productive performance and intestinal morphometry of the growing rabbits. Study Design: Laboratory experimental design was used in this study. Place and Duration of Study: The study was conducted in the experimental rabbitry of Physiology Department, Faculty of Veterinary Medicine Cairo University, Egypt. The s duration of the study persists for 70 days. Methodology: Thirty- two apparently healthy male New Zealand rabbits with average body weight of 544 ± 9 g were divided randomly into four dietary treatments at weaning (28 th day of age). The control group (C) was fed on standard basal diet with no supplementation. Rabbits in the second group (T1) received the same basal diet supplemented with CM3000 ® 500 g/ton feed. Animals in the third group (T2) consumed th...