Assessment of Apo-B and TG/HDL-C Ratio as Indicators of Insulin Resistance in Patients with Metabolic Syndrome | Chapter 02 | Recent Advances in Biological Research Vol. 3
The concept of metabolic Syndrome was first introduced as Syndrome X by Gerald Reaven He delivered the Banting Lecture in 1988 at the American Diabetes Association national meeting. He stated that Syndrome X is aggregation of independent, risk factors present in the same individual which are seen in coronary heart disease (CHD). The various risk factors included in the syndrome were insulin resistance, defined as the inability of insulin to optimally stimulate the transport of glucose into the body’s cell (hyperinsulinemia or impared glucose tolerance, hypertension, hypertriglyceridemia, and low, high-density lipotrotein cholesterol (HDL) [1]. Syndrome X is referred as,the deadly quartet by Kaplan [2] and Foster described it as,a secret killer [3]. Reaven in his Banting Lecture described the point that insulin resistance/hyperinsulinemia might be the underlying cause of the syndrome. Reaven also suggested that insulin resistance/hyperinsulinemia was an underlying r...