B P International

The renin-angiotensin system (RAS) regulates blood pressure the most effectively, and angiotensin II is the main mediator in this system. Angiotensin II binds to AT1 receptors and causes a multitude of potentially detrimental effects, including blood pressure elevation, atherosclerosis progression, and myocardial and vascular hypertrophy. Losartan was the first angiotensin receptor blocker (ARB) to be identified to reduce the risk of stroke and new-onset diabetes, as well as having a proven stroke benefit. The purpose of this study was to see how losartan affected various biochemical markers. Over a six-month period, researchers looked at the effects of monodrug (Losartan) therapy on blood sugar, lipid profile, uric acid, and serum electrolytes. The researchers looked at twenty-nine newly diagnosed essential hypertension patients of both genders. Before starting losartan monotherapy, baseline values of lipid profile, serum electrolytes, fasting blood sugar, and uric acid were taken...

A  simple,  reliable, sensitive, reproducible and novel isocratic RP-HPLC method was developed and validated for the separation and quantitative estimation of four angiotensin II-receptor antagonists namely Telmisartan (TELM), Losartan (LOSA), Olmesartan (OLME) and Valsartan (VALS) that are utilized in treating hypertension alone or along with some other drugs like thiazide diuretics mostly Hydrochlorothiazide (HCTZ). The key important benefit of developed method was that the five individual drugs can be determined on a single chromatographic system without alteration in detection wavelength and mobile phase. All the above said drugs were separated by using Welchrom C18 column having internal diameter of 4.6 X 250 mm with 5 µm particle size as stationary phase with mobile phase consisting a mixture of acetonitrile and phosphate buffer (pH-3.3, 50:50 v/v). The mobile phase was pumped at a flow rate of 1 ml/min. The wave length of the UV detection was done at  238 nm. Th...