Lemongrass Leaf Extract Attenuates Hydrocarbon- Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats | Chapter 09 | Emerging Research in Medical Sciences Vol. 1
Aim: The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Methodology: Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4 and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively) and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Results: Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin c...