In vitro and ex vivo Studies of Nonionic Surfactant Vesicles Using 23 Factorial Design: Metoprolol Tartrate Used as Model Drug | Chapter 04 | Modern Advances in Pharmaceutical Research Vol. 2
The purpose of this study was to formulate and investigate metoprolol tartrate (MT) loaded non-ionic surfactant vesicles using 2 3 factorial designs. Preparation of niosomal drug delivery of MT increased its bioavailability which led to being better therapeutic effects, reduced the frequency of dosing and decreased side effects of hypertensive patients. Ether injection method (EIM) and thin film hydration method (TFHM) were used for the preparation of all formulations as per full factorial design to study the effect of two independent variables X1 (amount of span-60), and X2 (amount of cholesterol) on three dependent variable Y1 (percent drug entrapment efficiency), Y2 (percent drug content) and Y3 (percent cumulative drug release) respectively. The relation between the dependent and independent variables was drawn out from the mathematical equation and response surface methodology (RSM). Statistical analysis was performed using ANOVA. Microscopic observation confirmed that all par...