The Glutathione S-Transferase Activities in the Evaluation Acute Viral Hepatitis B and Chronic Alcoholic Liver Disease | Chapter 04 | New Insights into Disease and Pathogen Research Vol. 3
Glutathione S-Transferase is an important hepatic detoxifying enzyme. Half-life of GST alpha in plasma is about 1 hr; its concentration follows the changes in the hepatocellular damage more rapidly than aspartate amino transferase (AST) or alanine amino transferase (ALT). Aim and Objectives: To validate chronic alcoholic liver disease and acute viral hepatitis B could produce any significant changes in serum glutathione S-transferase activities. Materials and Methods: A total of 120 samples were used in the present research. 20 hepatitis B patient 40 chronic alcoholic hepatitis patients and 60 age and sex matched control subjects. Serum GST activity and standard LFT (Liver Function Test) parameters done. Results: GST activity showed a significantly increase (p value< 0.001) in chronic alcoholic liver disease patients (22.293±4.159 IU/L vs 20.127±4.789 IU/L) and in acute viral hepatitis (23.685±6.751 IU/L vs 20.127±4.789 IU/L). In multiple logistic regression ana...