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‘Research on Clinical Significance of Blood groups on Bleeding time and Clotting Time and its Association with Diseases; An Advanced Study’| Chapter 6 | New Frontiers in Medicine and Medical Research Vol. 5

Background: A person's blood group plays a unique role in revealing his or her identity. Certain diseases and psychological traits differ among ABO blood groups, according to studies. In addition, differences in bleeding tendencies among different blood groups have been revealed. As a result, a study was conducted to determine the relationship between bleeding time (BT) and clotting time (CT) and the ABO blood group. Methods and Materials: A cross-sectional study design was used in this investigation, which included 250 young individuals aged 18 to 24 years old. The ABO blood group was determined using the slide agglutination method, while the BT and CT blood groups were determined using the Dukes and capillary tube methods, respectively. Statistical Analysis: The correlation of BT and CT with blood group was investigated using Chi-square analysis. When the p value was less than 0.05, statistical significance was evaluated. The goal of this study was to discover the most common ABO...

Evaluation of the Haemostatic Activities of Sida corymbosa in Rats | Chapter 02 | Modern Advances in Pharmaceutical Research Vol. 3

Aims: To evaluate the anti-haemorrhagic activity of the leaf extract of Sida corymbosa in Wistar albino rats, a plant used to arrest bleeding in ethnomedical practices. Methods: The acute toxicity test was carried out in rats. The haemostatic activities of the extract were investigated using the tail bleeding time and amount of bleeding in rats; effects on haematological parameters were also evaluated in Wistar rats. Preliminary phytochemical analysis was conducted to detect the phytoconstituents of the extract of Sida corymbosa. Results: In this study, the oral LD 50 of the extract was found to be greater than 5 g/kg. Administration of the extract to rats for 14 days produced a dose-dependent and significant (P≤0.05) decrease in bleeding time and quantity of blood loss in pre-treated rats. On oral administration of the extract, the effects of the treatment on haematological parameters – White blood cells, Red blood cell, haemoglobin concentration were not significantly dif...