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Determining the Effectiveness of Addition of Drug Teneligliptin to Metformin, Glimepiride, Pioglitazone Combination in Type II Diabetic Patients | Chapter 06 | New Horizons in Medicine and Medical Research Vol. 1

 Diabetes is a widespread chronic disease that has spread to epidemic proportions in almost every developed and developing country. Diabetes is the leading cause of death in the world, affecting about 400 million people. Aims and Objectives: To investigate the efficacy of combining Teneligliptin with Metformin, Glimepiride, and Pioglitazone in type 2 diabetic patients. Methodology: This was a one-year cross-sectional study on type II diabetic patients conducted in the Department of Medicine at a tertiary health care centre from January 2017 to January 2018. Out of all type II diabetes patients, 40 were randomly selected for hypoglycemic therapy with the medications Metformin, Glimepiride, and Pioglitazone. Of these, 20 were continued on the prior treatment (Group B), while the remaining 20 were given the extra drug Teneligliptin (Group A). The statistical analysis was carried out using the SPSS 19 version of software and included an unpaired t-test and a chi-square test. The ...

Investigating the Potential Beneficial Effects of Native Banana Starch on Glycemia and Insulin Resistance in Obese Non-Diabetic Women| Chapter 4 | Issues and Development in Health Research Vol. 2

  Several studies have found that changing one's lifestyle can help minimise the risk of diabetes. The goal of this study was to compare the effects of native banana starch (NBS) and metformin (MF) on glycemic management and insulin resistance in non-diabetic obese women. HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR ( One group took NBS 30g/day and the other MF 850 mg/day for an eight-week period. Four weeks of NBS or four weeks of MF treatment lowered fasting glycemia (week 0 vs week 4, p0.05). Fasting insulin and HOMA-IR readings fell gradually after NBS and MF treatments, attaining statistical significance. After eight weeks (week 0 versus week 8, p-0.05), there was a statistically significant difference (week 0 vs week 8). After eight weeks of NBS supplementation, the 30 and 60 minute insulin AUCs tended to be lower than the baseline 30 and 60 minute insulin AUCs. After four or eight weeks, there...