B P International

The present study was undertaken to investigate the antioxidant and hepatoprotective effect of Spilanthes paniculata Wall. ex DC flower extracts against paracetamol-induced liver damage. The study was conducted in 36 male Wistar rats of either sex, and six groups were established. While the first group was maintained as normal control (NC, distilled water), Groups 2 to 6 were administered 3 g/kg Paracetamol (PAR) for 2 day, 100 mg/kg Silymarin (SMR), 500 mg/kg Methanolic extract (MESP), Petroleum ether extract (PEESP), Ethyl acetate extract of S. paniculata (EAESP) suspended in 0.5% tween 80 plus PAR, respectively. PAR was administered in the same schedule as in group 2, the treatment with silymarin and extracts was given for 10 days orally, respectively. It was observed that PAR significantly increased serum Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP) activity liver MDA levels (P<0.01) and significantly decreased liver Glutathione (GSH), ca...

Plants remain an important source of new drugs, new drug leads for making more effective drugs in the pharmaceutical industry. Plant based discovery resulted mainly in the development of anticancer and anti-infective agents providing new leads to the drug industry. The present article focuses on a unifying mode of action for the nutrients, namely, resveratrol, epigallocatechin, polyene-ß-carotene, polyene lycopene, piperine, curcumin, genistein, luteolin, sulforaphane and pomegranate extract. The mechanism is based on electron transfer, reactive oxygen species and oxidative stress, which comprises an extension of earlier reports involving agents. Most of the compounds are precursors of electron transfer quinones, whereas others fit into the polyene category. The nutrients are better known as antioxidants. The dichotomy is addressed.     Author(s) Details Peter Kovacic Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182-1030,...

Aims: As optimization of farm animals reproductive performance is a main objective, the present study was, undertaken to investigate the possible protective effect of vitamin C, vitamin E and olive pomace against dizocilpine (MK-801) induced oxidative stress and its resultant alterations on antioxidant status, spermiogram, hormonal, enzyme markers and histomorphology of testes of rabbit bucks during first and second month of the experiment. Study Design: Laboratory experimental design was performed. Place and Duration of Study: The study was conducted in the experimental rabbitry of Physiology Department, Faculty of Veterinary Medicine Cairo University during the period from January to May 2014 in accordance with the Chinese guidelines for animal welfare and approved by the animal welfare committee of Animal Science College, Zhejiang University. Methodology: Thirty- six male New Zealand White rabbits of about 5-months age and average body weight of 2500 g were randomly s...

Ayurvedic textbooks ascribe many therapeutic properties such as anti-inflammatory, antimicrobial and antioxidant actions to Sida cordifolia Linn. which contains many polyphenols in its roots and seeds.   Evaluation of in vivo antioxidant action in rats of the aqueous extract of Sida cordifolia Linn. roots has been done by introducing potassium dichromate for creating acute and chronic oxidative stress. The Folin- Ciocalteu reagent was utilized for assessing the phenol content which was determined as 27.375 mg Gallic acid/gm. During the acute toxicity tests using mice, no significant adverse signs or symptoms of toxicity were noticed up to the dose of 1500 mg/kg and no mortality was reported until this dosage. The Phosphomolybdate Assay using 3, 6 and 9 mg/ml of research drug concentrations resulted in determination of the Total Antioxidant Capacity that was found to be 15.40 ±9.13, 19.00 ±7.56 and 21.02 ±8.42 gm equivalents of Ascorbic acid. The results of the d-ROMs test which a...

Aims: To demonstrate that potassium ferrate will remove potentially toxic metal ions from contaminated water samples. Study Design: A known amount of metal ions were solubilized in aqueous solution, then exposed to potassium ferrate in known amounts. Extent of removal was monitored by ion chromatography and visible spectroscopy. Place and Duration of Study: Department of Chemistry, Durham Science Center, 6001 Dodge Street, Omaha Nebraska 68182 USA. Methodology: Known amounts of iron (II), manganese (II), copper (II), and calcium were solubilized in aqueous solution to known molarity. These mixtures were treated by utilizing potassium ferrate in known amounts. The presence of metal ions was monitored by ion chromatography and/or visible spectroscopy before and after treatment with potassium ferrate. Potassium ferrate was present with metallic ions for 24 hours at 21ºC. Results: Metal ions were placed in aqueous solution, iron (II) as Fe(NH4)2(SO4)2, copper (II) ...