Spilanthes paniculata Flower Extracts Attenuates Paracetamol Induced Liver Damage by Antioxidant Mechanism | Chapter 3 | Trends in Pharmaceutical Research and Development Vol. 1
The
present study was undertaken to investigate the antioxidant and hepatoprotective
effect of Spilanthes paniculata Wall. ex DC flower extracts against
paracetamol-induced liver damage. The study was conducted in 36 male Wistar
rats of either sex, and six groups were established. While the first group was
maintained as normal control (NC, distilled water), Groups 2 to 6 were
administered 3 g/kg Paracetamol (PAR) for 2 day, 100 mg/kg Silymarin (SMR), 500
mg/kg Methanolic extract (MESP), Petroleum ether extract (PEESP), Ethyl acetate
extract of S. paniculata (EAESP) suspended in 0.5% tween 80 plus PAR,
respectively. PAR was administered in the same schedule as in group 2, the
treatment with silymarin and extracts was given for 10 days orally,
respectively. It was observed that PAR significantly increased serum Alanine
transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP)
activity liver MDA levels (P<0.01) and significantly decreased liver
Glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) activity
(P<0.01), when compared with the normal control group (NC). On the other
hand, statistically significant (P<0.01) changes were observed in the
biochemical parameters of the group which was administered SMR, PEESP and
EAESP. Compared with the pathological changes observed in the liver in the form
of congested sinusoids and centrilobular necrosis, in the group which was
administered paracetamol alone (PAR), lesions were determined to be less severe
particularly in the group (PEESP and EAESP). The study shows that administration
of PEESP and EAESP offered a therapeutic potential for the treatment of
hepatotoxicity induced by paracetamol via regulation of endogenous antioxidant
system in liver.
Author(s) Details
Syed Ayaz Ali
Department of Pharmacology, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India.
Shukla Mahanand
Department of Pharmacology, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India.
Subur W. Khan
Department of Pharmacognosy, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/156
Author(s) Details
Syed Ayaz Ali
Department of Pharmacology, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India.
Shukla Mahanand
Department of Pharmacology, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India.
Subur W. Khan
Department of Pharmacognosy, Y. B. Chavan College of Pharmacy, Dr. Rafiq Zakaria Campus, Rauza Bagh, Aurangabad, Maharashtra, India
View Book :- http://bp.bookpi.org/index.php/bpi/catalog/book/156
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