Assessment of Dental Pulp Stem Cell (DPSC) Biomarkers Following Induction with Bone Morphogenic Protein 2 (BMP-2) | Chapter 12 | Advances and Trends in Biotechnology and Genetics Vol. 3
Introduction: Tissue regeneration and biomedical engineering are the goals of modern research that have made tremendous strides in recent years. Dental pulp stem cells (DPSCs) have been demonstrated to exhibit functional multipotency, differentiating into neurons, adipocytes, and other cell types. The primary goal of this study was to investigate the ability of bone morphogenic protein (BMP-2) to induce proliferation and differentiation of DPSC isolates into mineral forming bone cell precursor lineages. Study Design: This was a prospective study with the non-randomised experimental design. Place and Duration of Study: This study was conducted at the University of Nevada, Las Vegas – School of Dental Medicine between May 2017 and August 2018. Methodology: Eight previously isolated dental pulp stem cell (DPSC) isolates were grown in culture and treated with bone morphogenic protein (BMP-2) to evaluate any effects on growth, viability or biomarker expression. Results: BMP-2 induced...