Study about Oncogenic Human Papillomavirus in Breast Cancer: An Approach towards Molecular Prevalence in a Group of Congolese Patients | Chapter 05 | New Horizons in Medicine and Medical Research Vol. 6
Background: Several studies have revealed a possible link between the aetiology of breast cancer and viral infection since the Band's study in 1990. HPV infection is one of the cancer-causing viruses that has been related to breast cancer cases all over the world. The goal of this study was to seek for HPV DNA in archival paraffin-embedded breast cancer cases at the University Hospital of Brazzaville, and to see if there was a link between viral HPV infections and clinicopathological characteristics. Methods: Forty formalin-fixed paraffin-embedded (FFPE) samples were retrospectively collected, with all available data being documented. HPV was detected and genotyped using real-time PCR using GeneXpert technology (Cepheid®, Sunnyvale, USA). The average age of the participants was 51.1 11.4 years (range 22 - 75 years; median was 47). HPV DNA was identified in 6 (15%) of the breast cancer samples in total. HPV-16 was detected in 83.7 percent of all samples, making it the most fr...