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Study about Oncogenic Human Papillomavirus in Breast Cancer: An Approach towards Molecular Prevalence in a Group of Congolese Patients | Chapter 05 | New Horizons in Medicine and Medical Research Vol. 6

 Background: Several studies have revealed a possible link between the aetiology of breast cancer and viral infection since the Band's study in 1990. HPV infection is one of the cancer-causing viruses that has been related to breast cancer cases all over the world.

The goal of this study was to seek for HPV DNA in archival paraffin-embedded breast cancer cases at the University Hospital of Brazzaville, and to see if there was a link between viral HPV infections and clinicopathological characteristics.

Methods: Forty formalin-fixed paraffin-embedded (FFPE) samples were retrospectively collected, with all available data being documented. HPV was detected and genotyped using real-time PCR using GeneXpert technology (Cepheid®, Sunnyvale, USA).

The average age of the participants was 51.1 11.4 years (range 22 - 75 years; median was 47). HPV DNA was identified in 6 (15%) of the breast cancer samples in total. HPV-16 was detected in 83.7 percent of all samples, making it the most frequent genotype. There was no statistically significant relationship between HPV transmission and clinicopathological characteristics (p>0.05). However, there was a statistically significant relationship between HPV infection and SBR grade (p=0.05).

Conclusion: In Congolese women with breast cancer, we discovered a high frequency of HPV-HR. To properly characterise the potential impact of HPV in the incidence of breast cancer in Congo, more case-control studies are needed.

Author(S) Details

Luc Magloire Anicet Boumba
Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Congo and Laboratoire d’Analyses Médicales, Hôpital Général de LOANDJILI, Pointe-Noire, Congo and Laboratoire de Biologie Moléculaire HDL, Polyclinique Marie Madeleine GOMBES, Pointe-Noire, Congo and Zone de recherche de Pointe-Noire, Institut National de Recherche en Science de la Santé (IRSSA), Brazzaville, Congo.

Dimitri Malanda Mboungou Moudiongui
Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Congo and Service de laboratoire d’Anatomie et cytopathologie, Centre Hospitalier et Universitaire de Brazzaville, Congo.

Parfait Christy Nganga
Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Congo.

Donatien Moukassa
Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Congo.

Jean Félix Peko
Faculté des Sciences de la Santé, Université Marien NGOUABI, Brazzaville, Congo and Service de laboratoire d’Anatomie et cytopathologie, Centre Hospitalier et Universitaire de Brazzaville, Congo.

View Book:- https://stm.bookpi.org/NHMMR-V6/article/view/6436

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