B P International

Subacute sclerosing panencephalitis (SSPE) is a progressive degenerative disease caused by measles infection with overall poor prognosis in spite multiple modalities of treatment. The course of the disease is characterized by progressive neurological decline in the form of behavioral and personality changes followed by a stage of characteristic periodic myoclonic spasms followed by a stage of quadriplegia movement disorder, vegetative state and frequently early death. Here we report two cases with atypical presentation of early rather than late movement disorder during illness and the unusual association of central precocious puberty preceding the course of illness in one of the cases. Author(s) Details Hanin Al-Gethami Neuro-Science Center, King Fahd Medical City, Riyadh, Saudi Arabia Mohammad Talal Alrifai Pediatric Neurology Division, Department of Pediatrics, King Abdullah Specialist Children Hospital, King Abdulaziz Medical City, Riyadh, Saudi Arabia. Ahmed ...

Background: Primary squamous cell carcinoma of renal pelvis/kidney (PSCCRP/K) is rare with controversies regarding its histogenesis. Aim: To review the literature. Methods: Various internet data bases were searched. Literature Review: Few cases of PSCCRP/K have been reported with only three cases of PSCC of the renal parenchyma without involvement of renal pelvis. Some PSCCRP/Ks have been associated with renal calculi, chronic infections, vesicoureteric reflux. Some cases had developed many years following successful percutaneous nephrolithotomy; a case was reported many years after curative radiotherapy for testicular tumour. The tumours are initially diagnosed in advanced stages; generally the prognosis has been poor following nephrectomy/nephrouretectomy. Conventional radiology imaging features of the disease are non-specific and cannot differentiate the lesion from other tumours or xanthogranulomatous pyelonephritis. Diagnosis is based upon strict histopathological c...

Carcinosarcoma is a mixed malignant biphasic tumour representing a rare entity and comprises of both epithelial and mesenchymal components. Primary ovarian carcinosarcoma is a rare neoplasm with a number of cases reported in the literature in the hundreds. It accounts for less than 1% of all ovarian tumours. These tumours are usually diagnosed at older age and advanced stage. It has aggressive clinical behaviour and survival depends on stage at presentation. Radiological imagings cannot differentiate carcinosarcomas from other ovarian cancers. Diagnosis is based upon histological findings. Cytoreductive debulking surgery is a crucial part in the treatment of carcinosarcoma of ovary. The role of adjuvant chemotherapy regimen is still controversial. Combination chemotherapy with taxane and platinum based regimen or ifosfamide and platinum based regimen are considered as adjuvant treatment. Despite aggressive treatment modalities such as surgery and chemotherapy, the outcome is poor. R...