B P International

  Several studies have found that changing one's lifestyle can help minimise the risk of diabetes. The goal of this study was to compare the effects of native banana starch (NBS) and metformin (MF) on glycemic management and insulin resistance in non-diabetic obese women. HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR (ge)2.5 HOMA- IR ( One group took NBS 30g/day and the other MF 850 mg/day for an eight-week period. Four weeks of NBS or four weeks of MF treatment lowered fasting glycemia (week 0 vs week 4, p0.05). Fasting insulin and HOMA-IR readings fell gradually after NBS and MF treatments, attaining statistical significance. After eight weeks (week 0 versus week 8, p-0.05), there was a statistically significant difference (week 0 vs week 8). After eight weeks of NBS supplementation, the 30 and 60 minute insulin AUCs tended to be lower than the baseline 30 and 60 minute insulin AUCs. After four or eight weeks, there...

  For a long time, it was assumed that, while weight loss was necessary and desired, comorbidities were far more significant and required treatment, preferably with medication, even if weight loss was not a treatment objective. This disagreement causes therapy to be postponed, which then leads to overly extensive medical treatment. As a result, health-care expenses have risen to unacceptably high levels, resulting in the medicalization of individuals and a decline in patient responsibility for their own health, leaving it up to individuals to decide when their own weight is an issue that needs to be addressed. The goal of this study was to gather evidence to support a paradigm change in regards to the association between body weight and comorbidities. Insulin resistance is the root of the problem, which leads to a slew of other health issues. To ensure better tailor-made treatment for patients, this illness should be diagnosed at primary care and obesity clinics. Treatment for insu...

Objective: To evaluate the role of Fetuin A levels in predicting glycemic outcome in individuals with impaired fasting glucose. Research Design and Methods: A total of 742 young individuals were recruited for the study out of which 177 had impaired fasting glucose, 468 had normoglycemia and 97 individuals with diabetes. These individuals were offsprings of diabetics (either mother or father or both) and were siblings amongst themselves belonging to age group of 18-35 years. Various biochemical investigations such as fasting plasma glucose, glycosylated Hb, serum insulin, C-peptide and Fetuin A were carried out. People with impaired fasting glucose were followed and analyzed according to glycemic outcome and quartile of Fetuin A level. Results: A total of 66 individuals with prediabetes reverted back to normal, 28 progressed to diabetes and 83 remained with prediabetes over a mean±S.D follow up of 24±4.1 months. People in the highest quartile of fetuin A had the hi...

Decreased insulin secretion due to beta cell dysfunction of the pancreas and defective utilization of insulin due to insulin resistance / Hyperinsulinemia are two important issues in the pathogenesis of DM2. There are many explanations in the literature to account for these two observed phenomena and their interrelationship. DM2 is believed to occur due to a complex interplay of environmental and Behavioural factors in genetically predisposed persons. Among the theories explaining the pathogenesis of DM2, the viscera- Portal hypothesis, the Ectopic fat hypothesis and the adipose tissue as an endocrinal gland are prominent. Besides, the role played by oxidative stress, metabolic stress, mitochondrial dysfunction, endoplasmic reticulum stress, etc. are also advanced. It is felt that basic to and at the core of all the observed facts, is the shift of energy metabolism from normal glycolysis to B- oxidation of fats. Hence, how B - oxidation prevails over glycolysis is the fundamental is...

The concept of metabolic Syndrome was first introduced as Syndrome X by Gerald Reaven He delivered the Banting Lecture in 1988 at the American Diabetes Association national meeting. He stated that Syndrome X is aggregation of independent, risk factors present in the same individual which are seen in coronary heart disease (CHD). The various risk factors included in the syndrome were insulin resistance, defined as the inability of insulin to optimally stimulate the transport of     glucose into the body’s cell (hyperinsulinemia or impared glucose tolerance, hypertension, hypertriglyceridemia, and low, high-density lipotrotein cholesterol (HDL) [1]. Syndrome X is referred as,the deadly quartet by Kaplan [2] and Foster described it as,a secret killer [3]. Reaven in his Banting Lecture described the point that insulin resistance/hyperinsulinemia might be the underlying cause of the syndrome. Reaven also suggested that insulin resistance/hyperinsulinemia was an underlying r...