Usefulness of Presepsin Concentrations for Differentiating Sepsis Severity | Chapter 06 | New Horizons in Medicine and Medical Research Vol. 6
The importance of early detection and treatment of sepsis is critical for a better clinical outcome. For the quick diagnosis of sepsis, many sepsis biomarkers are commonly employed. This study looked into the diagnostic accuracy of presepsin, procalcitonin (PCT), and C-reactive protein (CRP) in distinguishing sepsis severity, as well as their link with the Sepsis-related Organ Failure Assessment (SOFA) score. 100 septic patients from two university clinical centres were enrolled in the trial during two time periods. The Sepsis-3 definitions were used to stratify the patients. Biomarkers and the SOFA score were measured four times during the illness. A sandwich ELISA kit was used to measure presepsin. A generalised linear mixed effects model was used to assess changes in biomarker concentrations and SOFA score values during the illness, as well as to quantify differences across severity groups. Multivariate analysis was used to look into the relationship between biomarkers and SO...