Preparation of Bisoprolol Impurity A of High Quality | Chapter 7 | Theory and Applications of Chemistry Vol. 2
Aims: Research on the convenient method for obtaining (RS)-1-(4-Hydroxymethyl-phenoxy)-3-isopropylaminopropan-2-ol, known as the Impurity A of Bisoprolol according to EP, of high quality. Study Design: Impurity A may be formed as a by-product in the common processes used for synthesis of bisoprolol fumarate. Impurity A may be also formed as a result of degradation (hydrolysis) of Bisoprolol. This chemical compound is available as the reference standard, but the offered purity is between 95% and 97%, what suggest that its purification to high quality is demanding. The most common method used for purification of chemical standards is preparative chromatography, but it is unattainable in many cases. There is continuous need for simple, convenient and repeatable laboratory procedures. Methodology: The synthesis of Bisoprolol Impurity A was performed starting from p-hydroxybenzyl alcohol and subsequent reactions with epichlorohydrin and is opropylamine. Purificatio...