FOETAL Organ Implantation into Adult Animals: A Model for In vivo Culture of Stem Cells? | Chapter 1 | Highlights on Medicine and Medical Science Vol. 18
Background: Because of the increased need and capacity to provide these interventions, stem cell implantations are increasingly being developed and used in clinics as an alternative and complementary solution to adult organ transplantation. However, there are significant drawbacks to using stem cells (for instance integration within the recipient organism of engineered tissues and organoids obtained in vitro from stem cells). In vivo studies of stem cell development and evaluation of the host's participation in this process may be possible via foetal organ implantation in adult animals. The goal of this study was to test various foetal organ implants. Part I: Different sites of foetal organ syngeneic implantation were postulated in over 650 investigations on rats and mice. Implant development was assessed using physiological (electric activity, motor and secretory activities) and morphological (per illumination, ultra sound and magnetic imaging, optic and electron microscopy) app...