The Ni(II) Complex of 2-Hydroxy-Pyridine-N-Oxide 2-Isothionate: Synthesis, Characterization, Biological Studies, and X-ray Crystal Structures Using (1) Cu Kα Data and (2) Synchrotron Data | Chapter 09 | New Advances in Materials Science and Engineering Vol. 2
C 12 H 20 N 6 NiO 6 S 2 or NiL 2 (SCN) 2 ](NH 4 ) 2. 2H2O, where L is 2-hydroxy-pyridine-N-oxide, has been prepared and characterized using elemental analyses, IR, UV and visible spectrometry, magnetic moment measurements, thermal analyses and single crystal X-ray analyis. The results indicate that the complex reacts as a bidentate ligand and is bound to the metal ion via the two oxygen atoms of the ligand (HL). The activation energies, ∆E*, entropies ∆S*, enthalpies ∆H* and order of reactions have been derived from differential thermo-gravimetric (DTA) curves. Based on inhibition zone diameter measurements, the complex exhibited significant antibacterial activity against both Staphylococcus aureus and Escherichia coli. It also exhibited significant antifungal activity against Candida albicans, but no activity was found against Aspergillus flavus. The crystal structure of the Ni(II) complex [C 12 H 20 N 6 Ni O 6 S 2 ], Mr = 467.17, was determined from Cu Kα X-ray diffraction da...