B P International

 Acetophenone 2', 4'- dihydroxy semicarbazone [A24DHS], a novel analytical reagent, is proposed as a spectrophotometric reagent for U (VI). NMR, IR, and elemental analysis are used to characterise the reagent A24DHS, which is synthesised in the lab. In an acidic aqueous solution (pH = 7.4), a spectrophotometric method is presented for the trace determination of U(VI) using A24DHS as a spectrophotometric reagent ((lambda)max = 340 nm). In the concentration range of 1 to 10 ppm, Beer's law is followed. The A24DHS creates a coloured complex with a ratio of 1:2. With a molar absorptivity of 2896.43 L mol-1 cm-1, Sandell's Sensitivity is 0.0823 (mu)g cm-2. The proposed method has been used to determine Uranium in ores and commercial samples with great success. The precision and accuracy obtained were adequate for use in the industry in question. This chapter details the method development for determination of Uranium in different commercial samples. Author (S) Details Ya...

A simple, sensitive and accurate kinetic spectrophotometric method for the determination of Rizatriptan Benzoate in pure and dosage form is described. The method is based on spectrophotometrically monitored oxidation of the drug by a known excess of Chloramine-B in HCl medium using initial rate, fixed time and variable time method in HCl medium. The oxidized product exhibits a maximum absorption at 490nm. The apparent molar absorptivity and Sandell’s sensitivity values are in the range 2.97 x 10 4 to 0.0198 respectively. The proposed method has been successfully applied to the determination of RTB in commercial pharmaceutical formulations. Statistical comparison of the results with well-established reported method shows agreement in terms of precision and accuracy. Author(s) Details S. Malini Department of Chemistry, Dayananda Sagar College of Engineering, Bangalore-560 078, India. Kalyan Raj Department of Chemistry, BMS College of Engineering, Bangalore-560 019, Ind...