Synthesis, Characterization and Antibacterial Activity of Methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]Tryptophanate| Chapter 14 | Theory and Applications of Chemistry Vol. 4
The title compound, methyl N -[1-(benzoylamino)-2-methoxy-2-oxoethyl]tryptophanate 2, have been synthesized in high yield, via N -alkylation reaction of methyl 2-azido-2-benzamidoacetate with methyl 2-amino-3-(1 H -indol-3-yl)propanoate in acetone, with the presence of diisopropylethylamine as a base. The structure of the prepared compound was characterized by 1 H, 13 C NMR in addition to MS, X-Ray diffraction data, and elemental analysis. This compound was tested in vitro for its antibacterial activity against Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus , and Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric . The MIC values showed that the synthesized compound had a bactericidal effect against the strains tested. Author(s) Details Oumaima Karai Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco Younas Aouine Organic C...