Association between Immunoglobulin G Subtypes Immune responses to Plasmodium falciparum Merozoite Surface Protein 1-19 and Malaria | Chapter 10 | Current Trends in Disease and Health Vol. 1
Aims: To determine Immunoglobulin G (IgG) subtypes (IgG1, IgG2, IgG3 and IgG4) responses to PfMSP1 -19 antigens and their associations with malaria across different age groups. Study Design: A community based cross sectional study. Place and Duration of Study: Bondo Ward, in Handeni district of Tanga Region between January and May 2016. Methodology: We included 331 participants; 216 females, 115 males aged between 1 and 82 years, with a median age of 10 years and an inter-quartile range 5 -30 years. Two milliliters of blood was collected from each participant in EDTA coated tubes for detection of malaria and serology. Anti-MSP1-19 IgG subtypes were measured by indirect ELISA based on a protocol developed by Afro Immuno-Assay Consortium. Demographic data were collected using designed record form. Results: Out of 331 participants, 68 (20.5%) were malaria positive. We report malaria prevalence to be highest in the age category of between 6 a...