B P International

  Mannich reaction and cyclo condensation were used to make the compounds 7,9-diphenyl-1,4-dioxa-8-azaspiro[4.5]decane 1-6. Elemental analysis, mass, IR, 1H,13C, and NMR studies were used to determine the structures and stereochemistry. Elemental analysis was used to verify the purity. By coupling constant values of 1H NMR, the synthesised compounds 1-6 adopt chair conformation with equatorial orientation of the aryl groups. Antibacterial activity against Proteus mirabilis, Klebsiella oxytoca, Staphylococcus aureus, and Salmonella paratyphi was tested on all of the compounds. In vitro antibacterial activity of compound 5 was excellent in all species.   Author (S) Details Manivannan Natarajan Department of Chemistry, Ramakrishna Mission Vivekananda College (Autonomous), Mylapore, Chennai-600004, India. Elanchezhian Balachandravinayagam Department of Chemistry, A.V.C. College (Autonomous), Mannampandal, Mayiladuthurai-609305, India. Selvanathan Ganesan Department of...

Rhamnus prinoides finds therapeutic applications in traditional medicine in Southern Africa, which include treating pulmonary tuberculosis (TB), pneumonia, gonorrhoea, muscular rheumatism, cleaning the blood, bladder and kidneys. Hexane, chloroform, ethyl acetate and methanolic extracts from leaves and stem-bark of R. prinoides have been evaluated for their antioxidant activity by 1,1diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. The percentage values of radical of scavenging activity of these extracts have been found to be in the range of 03.33±0.89 to 59.55±2.27% at various concentrations. The IC50 values of these extracts have been determined to be in the range of 710.50 to >3000 µg mL-1. The positive control, ascorbic acid, showed an IC50 value of <200 µg mL-1. Additionally, all these extracts have also been evaluated for their inhibitory effect against six bacterial isolates viz. Escherichia coli (wild), Escherichia coli (H0157), Staphylococcus aureus, Listeria...

Nasal carriers of Staphylococcus aureus are important reservoirs with risk of developing endogenous infections or transmitting infections to susceptible individuals. Methicillin-resistant S. aureus (MRSA) are associated with higher rates of treatment failure. Some strains of S. aureus produce slime which is believed to make the microorganisms more resistant to antibiotics and host defenses. The antibacterial activity of ethyl acetate: n-hexane (EtOAc:HEX) extracts of Mulinum spinosum (5:95% EtOAc:HEX, 50:50% EtOAc:HEX, 70:30% EtOAc:HEX and   mix 20:80/30:70% EtOAc:HEX, 50:50/70:30/100:0% EtOAc:HEX) were assayed against 3 slime-producing S. aureus strains and 2 MRSA strains isolated from nasal carriers. S.aureus ATCC 35556 slime-producing strain and MRSA ATCC 43300 strain were used as controls. The extracts were prepared using flash chromatography. M. spinosum 5:95% AcOEt:HEX showed antibacterial effect against all slime-producing strains (MIC:500 µg/ml) and the highest activity ...

Piper longum is a medicinal plant of great importance. The present work is to compare anticancerous, antibacterial and antioxidant properties of different explants (leaf and stem) of Piper longum in vivo and in vitro. The anticancerous activity was measured in terms of percentage cytotoxicity and the cell line used was leukemic cell line K562. Escherichia coli, Bacillus subtilis and Staphylococcus aureus, bacteria were used for determination of antibacterial activity. Solvent extracts were prepared from leaf and stem explants of Piper longum and their anticancerous, antibacterial and antioxidant activities were evaluated. Antioxidant activity was measured in terms of percentage (%) Total Phenolic Content (TPC) and percentage (%) 2,2– diphenyl 1-2-picryl hydrazy1 (DPPH) radical scavenging capacity. The aqueous Piper longum fruit extract and green synthesized silver nanoparticles showed powerful antioxidant properties in in vitro studies. The anticancerous, antibacterial and antioxida...

The title compound, methyl N -[1-(benzoylamino)-2-methoxy-2-oxoethyl]tryptophanate 2, have been synthesized in high yield, via N -alkylation reaction of methyl 2-azido-2-benzamidoacetate with methyl 2-amino-3-(1 H -indol-3-yl)propanoate in acetone, with the presence of diisopropylethylamine as a base. The structure of the prepared compound was characterized by 1 H, 13 C NMR in addition to MS, X-Ray diffraction data, and elemental analysis. This compound was tested in vitro for its antibacterial activity against Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus , and Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa and Salmonella enteric . The MIC values showed that the synthesized compound had a bactericidal effect against the strains tested. Author(s) Details Oumaima Karai Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco Younas Aouine Organic C...

The amino ester derivative was synthesized via N -alkylation of methyl a -azido glycinate N -benzoylated 1 with methyl 2-amino-2-phenylacetate in methylene chloride and in presence of triethylamine as basic catalyst. The structure of the prepared compound was determined by spectroscopic methods: 1 H-NMR, 13 C-NMR, MS data, elemental analysis and confirmed by X-Ray diffraction. This compound was screened in vitro for its antibacterial activity against Gram-positive bacteria ( Bacillus subtilis and Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli , Pseudomonas aeruginosa and Salmonella enteric ) . The synthesized compound showed an interesting inhibitory effect against all the strains tested. Author(s) Details Hassane Faraj Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco. Abdelilah El Hallaoui Organic Chemistry Laboratory (LCO), Faculty of Sciences Dha...

The compound, diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate 2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate in the absence of a solvent. The structure of the synthesized compound was established on the basis of NMR spectroscopy (1H, 13C), X-ray crystallography and MS data. The prepared compound was also tested in vitro for its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). The calculation of MBC/MIC ratio showed that this triazole derivative 2 had a bactericidal effect on the two strains tested. Author(s) Details Hassane Faraj Organic Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000, Morocco. Abdelilah El Hallaoui Organic Chemistry Laboratory (LCO), Faculty ...

The emergence of antibiotic resistance as well as the recent undesirable side effect of some of the commercially available antibiotics has led to the screening of plant extract in order to discover new drug that could serve as alternative therapy for the treatment of various infections and diseases. Fresh leaf of Ocimum gratissimum (scent leaf) sample was collected, air-dried at room temperature and blended to powder using electric blender. The extraction was done using reflux extraction method and methanol as solvent. The phytochemical analysis and the antibacterial activity of O. gratissimum were determined to ascertain the different phytochemicals present in the plant extract. The extract was also tested against some selected Gram negative intestinal pathogenic bacteria; Escherichia coli, Shigella and Salmonella species, by reconstituting the extract in dimethyl sulphoxide (DMSO) to obtain different concentration (0.2, 0.1, 0.05 and 0.025 g/ml) and agar well diffusion techniques w...

Introduction: Plants are a limitless gift of nature to humans and they possess very appreciative values and roles. They have stood the test of time in the life of man since creation. All over the world, they are hugely exploited for food, fuel, timber, medicine etc. The natural endowment of plants with numerous metabolites and bioactive compounds makes them good sources of therapeutic agents capable of replacing synthetic antibiotics; For example, Salversan and Penicillin are synthetic drugs formerly used for the treatment of Syphilis and Staphylococcus aureus infections, respectively, but which became less preferred because these pathogens developed resistance to the drugs. Aim: This study was aimed at evaluating Euphorbia abyssinica (Desert Candle), a medicinal plant extensively used in folklore medicine among the Kendem people of South-west Cameroon for antibacterial activity and extracts analyzed for phytochemical composition. Study Design: The completely rand...