Characterization and Antibacterial Activity of New -Aminoester Derivative, Synthesized via N-Alkyaltion of Methyl - Azido Glycinate| Chapter 9 | Theory and Applications of Chemistry Vol. 4
The amino ester derivative was synthesized via N-alkylation
of methyl a-azido glycinate N-benzoylated 1 with methyl 2-amino-2-phenylacetate in methylene chloride and in
presence of triethylamine as basic catalyst. The structure of the prepared
compound was determined by spectroscopic methods: 1H-NMR, 13C-NMR,
MS data, elemental analysis and confirmed by X-Ray diffraction. This compound
was screened in vitro for its antibacterial activity against
Gram-positive bacteria (Bacillus subtilis and Staphylococcus aureus) and
Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and
Salmonella enteric). The
synthesized compound showed an interesting inhibitory effect against all the
strains tested.
Author(s) Details
Hassane Faraj
Organic
Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed
Ben Abdellah University, P.B. 2626, Fez 30000, Morocco.
Abdelilah El Hallaoui
Organic
Chemistry Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed
Ben Abdellah University, P.B. 2626, Fez 30000, Morocco
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