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Rhamnus prinoides - A Basotho Medicinal Plant with Antioxidant and Antimicrobial Potential |Chapter 11 | Trends in Pharmaceutical Research and Development Vol. 1

Rhamnus prinoides finds therapeutic applications in traditional medicine in Southern Africa, which include treating pulmonary tuberculosis (TB), pneumonia, gonorrhoea, muscular rheumatism, cleaning the blood, bladder and kidneys. Hexane, chloroform, ethyl acetate and methanolic extracts from leaves and stem-bark of R. prinoides have been evaluated for their antioxidant activity by 1,1diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay. The percentage values of radical of scavenging activity of these extracts have been found to be in the range of 03.33±0.89 to 59.55±2.27% at various concentrations. The IC50 values of these extracts have been determined to be in the range of 710.50 to >3000 µg mL-1. The positive control, ascorbic acid, showed an IC50 value of <200 µg mL-1. Additionally, all these extracts have also been evaluated for their inhibitory effect against six bacterial isolates viz. Escherichia coli (wild), Escherichia coli (H0157), Staphylococcus aureus, Listeria monocytogens, Pseudomonas spp. and Serratia marcescens and two fungal isolates viz. Penicillium digitatum and Candida albicans. The zones of inhibition have been found to be in the range of 8.8±3.0 to 15.8±1.4 mm diameter against bacterial isolates and 10.3±1.8 to 14.3±2.5 mm diameter against fungal isolates. The minimum inhibitory concentrations (MICs) of these extracts have been found to be in the range of <31.25 to > 1000 µg/mL. Further studies on this plant will be useful to commercialize products from this plant.

Author(s) Details
Dr. Manoharan Karuppiah Pillai
Department of Chemistry and Chemical Technology, Faculty of Science and Technology, National University of Lesotho, Roma Campus, P.O. Roma 180, Kingdom of Lesotho

Dr. Sibusisiwe Magama
Department of Biology, Faculty of Science and Technology, National University of Lesotho, Roma Campus, P.O. Roma 180, Kingdom of Lesotho.

Ms. Lehlohonolo Isaac Santi
Department of Chemistry and Chemical Technology, Faculty of Science and Technology, National University of Lesotho, Roma Campus, P.O. Roma 180, Kingdom of Lesotho.

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