Synthesis, Characterization and Antibacterial Activity of Diethyl 1-((4-Methyl-2-phenyl- 4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate: Advanced Study| Chapter 8|Theory and Applications of Chemistry Vol. 4
The compound, diethyl
1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate
2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of
4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate
in the absence of a solvent. The structure of the synthesized compound was
established on the basis of NMR spectroscopy (1H, 13C), X-ray crystallography
and MS data. The prepared compound was also tested in vitro for its
antibacterial activity against Gram-positive bacteria (Staphylococcus aureus)
and Gram-negative bacteria (Escherichia coli). The calculation of MBC/MIC ratio
showed that this triazole derivative 2 had a bactericidal effect on the two
strains tested.
Author(s) Details
Hassane Faraj
Organic Chemistry
Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben
Abdellah University, P.B. 2626, Fez 30000, Morocco.
Abdelilah El Hallaoui
Organic Chemistry
Laboratory (LCO), Faculty of Sciences Dhar El Mahraz, Sidi Mohammed Ben
Abdellah University, P.B. 2626, Fez 30000, Morocco.
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