Synthesis, Characterization and Antibacterial Activity of Methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]Tryptophanate| Chapter 14 | Theory and Applications of Chemistry Vol. 4
The title compound, methyl N-[1-(benzoylamino)-2-methoxy-2-oxoethyl]tryptophanate 2, have been synthesized in high yield,
via N-alkylation reaction of methyl
2-azido-2-benzamidoacetate with methyl 2-amino-3-(1H-indol-3-yl)propanoate in acetone, with the presence of
diisopropylethylamine as a base. The structure of the prepared compound was
characterized by 1H, 13C NMR in addition to MS, X-Ray
diffraction data, and elemental analysis. This compound was tested in vitro for its antibacterial activity
against Gram-positive bacteria, Bacillus
subtilis and Staphylococcus aureus,
and Gram-negative bacteria, Escherichia
coli, Pseudomonas aeruginosa and Salmonella
enteric. The MIC values showed that the synthesized compound had a
bactericidal effect against the strains tested.
Author(s) Details
Oumaima Karai
Organic Chemistry Laboratory (LCO), Faculty of Sciences
Dhar El Mahraz, Sidi Mohammed Ben Abdellah University, P.B. 2626, Fez 30000,
Morocco
Hassane
Faraj
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