Squamous Cell Carcinoma of the Kidney and Renal Pelvis: A Review and Update of the Literature | Chapter 06 | New Insights into Disease and Pathogen Research Vol. 4
Background:
Primary squamous cell carcinoma of renal pelvis/kidney (PSCCRP/K) is rare with
controversies regarding its histogenesis.
Aim: To review the literature.
Methods: Various internet data bases
were searched.
Literature Review: Few cases of PSCCRP/K have been
reported with only three cases of PSCC of the renal parenchyma without
involvement of renal pelvis. Some PSCCRP/Ks have been associated with renal
calculi, chronic infections, vesicoureteric reflux. Some cases had developed
many years following successful percutaneous nephrolithotomy; a case was
reported many years after curative radiotherapy for testicular tumour. The
tumours are initially diagnosed in advanced stages; generally the prognosis has
been poor following nephrectomy/nephrouretectomy. Conventional radiology
imaging features of the disease are non-specific and cannot differentiate the
lesion from other tumours or xanthogranulomatous pyelonephritis. Diagnosis is
based upon strict histopathological criteria of the microscopic characteristics
of the tumour. Primary tumour elsewhere should be excluded with radiological
imaging. PSCCRP/K should be suspected when a renal/renal pelvis mass is found
with a history of chronic or past stone disease treatment. Perhaps if patients
who have undergone treatment for kidney stones are carefully followed-up with
radiological imaging, (for example, ultra-sound-scans and/or MRI and when
eventually required a CT scan properly indicated and performed) for a long
time, PSCCR/Ks may be diagnosed at an early stage of the disease in order to
provide early curative treatment.
Conclusions: PSCCRP/Ks have been
reported sporadically and a number of them have been associated with renal
calculi and chronic infections of the urinary tract. These malignancies on the
whole are initially diagnosed in advanced stages and hence associated with poor
prognosis. Histopathology examination of the lesion so far is the definite way
to confirm the diagnosis. PSCCRP/K should be considered a differential
diagnosis when a patient is found to have a renal / renal pelvis mass and a
history of treatment for renal pelvis calculi, or chronic inflammations.
Author(s) Details
Anthony Kodzo-Grey Venyo
[MB ChB FRCS(Ed) FRCSI FGCS Urol. LLM]
Department of Urology, North
Manchester General Hospital, Manchester, United Kingdom.
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